Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer

نویسندگان

  • Nadia Harbeck
  • Ronald E. Kates
  • Katja Gauger
  • Amina Willems
  • Marion Kiechle
  • Viktor Magdolen
  • Manfred Schmitt
چکیده

The serine protease urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-1, are key players in a proteolytic cascade involved in physiological and pathophysiological degradation and remodelling of the extracellular matrix. uPA, when bound to its cellular receptor uPA-R (CD87) efficiently converts plasminogen into the broad spectrum serine protease plasmin; its action on plasminogen is controlled by the serine protease inhibitors PAI-1 and PAI-2. Plasmin disintegrates various components of the connective tissue, and in malignancy, the tumor stroma surrounding the tumor cell nests. Interaction of PAI-1 with the uPA/uPA-R-complex induces internalization of the ternary complex uPA-R/uPA/PAI-1 via help of transmembrane Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer

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تاریخ انتشار 2017